The mechanisms of DNA replication and repair are subjects of intense interest and research, especially in terms of how dysfunction and failure in these mechanism may give rise to human diseases. This new collection of research presents the latest from the field, drawing on worldwide research. Part one offers studies of DNA replication and related cellular processes, including reverse transcriptase and retroviral replication. Part two focuses on the mechanisms of DNA replication, and includes new findings on intrinsically disordered proteins in the replication process, and the role of WRN helicase/exonuclease in DNA replication. Part three presents recent advances in the study of DNA replication. Contributors consider topics including strand-specific composition bias in bacterial genomes, and the organization of replisomes. In part four, new expert research is offered on fundamental aspects of DNA replications. Chapters range across subjects including initiation of DNA replication from closed circular DNA and the function of DNA polymerase ? in a replication fork. Finally, part five reviews topics in DNA repair. The reader will find new insights into topics including cell cycle and DNA damage response in postmitotic neurons. This diverse book will be essential for readers seeking new, high-quality studies in the field.
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