Mass spectrometry is enormously versatile, and has evolved considerably since it was first used commercially in the middle of the last century. One specific technique - tandem mass spectrometry - has broadened the scope of mass spectrometry considerably, because it can be used for structural analysis of complex organic molecules including peptides and oligonucleotides.
This book describes the basic principles of tandem mass spectrometry, including fragmentation methods and the matrix effect and techniques used to compensate for it. A large number of specific applications for tandem mass spectrometry are discussed in detail, namely the study of reaction kinetics, qualitative and quantitative analysis of biological samples, drug discovery/development, proteomics and metabolomics, and clinical studies in veterinary and human medicine. An example of the latter is the screening of newborn babies for hormones and metabolites that indicate the presence of inherited diseases such as disorders of sphingolipid metabolism.
We believe this book will be a useful reference for students across a number of disciplines in chemistry and the life sciences. It will also serve as a source of insight and ideas for researchers in these disciplines, both in industry and the academic world.
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