The oxidative stress caused by reactive oxygen species can cause DNA damage that may have major long-term effects on the body. Indeed, oxidative stress is a factor in the development of various diseases, including cancer, type II diabetes and neurodegenerative and cardiovascular disorders. However, there are a number of promising antioxidant-based treatments for these disorders, and this book discusses some of them in detail. The book also describes potential oxidant-based therapies such as the use of amitriptyline for treatment of cancer, as well as diagnostic applications, e.g. oxidatively-modified compounds as biomarkers for coronary artery disease.
The book will also discuss the molecular mechanisms associated with oxidative stress, their relationship with other pathways that can occur in the body, and how physiological changes such as menopause, aging and pregnancy can play a part. Various non-medical topics will also be discussed, including the mechanisms of stress toleration in potato crops and the link between pollutants and oxidative stress in fish.
We believe that this book is a valuable source of insight for students and researchers working in the fields of biochemistry, pharmacology, medical biology and molecular biology, as well as medical students and clinicians wishing to gain a greater understanding of this fascinating topic.
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