Since the work done by Watson and Crick in the middle of the last century, we have made enormous strides in terms of understanding DNA structure and also its mechanisms of replication, damage and repair. We are also gaining an insight into the role these mechanisms play in biological processes such as the development of certain types of disease.
This book provides a detailed description of some basic principles of DNA structure, replication and repair, and gathers together some of the current research and thinking on the subject. Subjects covered include non B-DNAs (and the mechanisms involved in transition between different types of DNA), telomeric DNA/telomer maintenance and shortening, epigenetic modifications that occur during DNA replication, assays for measuring DNA repair, the use of DNA repair proteins for targeted cancer treatment, and the molecular processes that control DNA replication during the cell cycle.
Specific types of organism discussed include hepatitis B virus, papillomavirus, Archaea, S. cerevisiae, and plants such as the Scots pine.
We believe that this book will be highly useful for upper level undergraduate and graduate students in biochemistry and molecular biology, as well as providing a valuable reference source for practitioners and researchers in these disciplines. "
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