The process of DNA repair in cells is a constant one, and is done to reverse damage caused by normal cellular activity and environmental factors including ultraviolet light, chemicals and ionizing radiation. Failure in the repair mechanism can result in irreversible damage to DNA structure and crosslinkages, leading to the pathological processes of aging and cancer. Furthermore, there are a number of hereditary genetic repair disorders that result in premature aging and mental retardation.
This book is a compilation of chapters on basic principles and concepts in DNA repair. One main focus of the book is the pathways involved in fixing damage and errors in fundamental cellular components such as mitochondria, as well as special classes of cells including stem cells.
Further chapters discuss DNA damage mechanisms, markers and DNA repair following exposure to environmental factors including oxidative stress, polycyclic aromatic hydrocarbons and radionuclide contamination. Another key area of focus for the book is the relevance of DNA damage to human health, and the possible applications in cancer treatment.
The target market for this book is those involved in research on cellular and molecular genetics, as well as clinicians in relevant disciplines and those working on drug discovery.
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