Bioinformatics is an increasingly important interdisciplinary field which has given rise to an explosion of ground-breaking research at the interface of computer science and molecular biology. This new book gathers expert contributions in this dynamic area to showcase current applications and directions for future development. In the first part, principles of bioinformatics are explored through topics such as incorporating the simulation of molecular dynamics into rational drug design, and ensemble clustering for biological datasets. In the second part, trends and methodologies come into focus. Chapters discuss subjects including vector space information retrieval techniques, on-chip living-cell microarrays for network biology, and novel machine learning techniques for microarray data classification. In the final part, selected research in practical contexts is presented. Subjects include bioinformatics software for data analysis in studies of osteoporosis, and flexible protein-protein docking. Chapters draw on expert contributions from around the world, and each is supported by a review of the relevant literature, ensuring that this is both a source of insights for current challenges and an excellent starting point for further research.
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